If products are being used off label for one of these reasons, it should be explained to the owner. The isoxazolines have also been used successfully off label for treatment of mites such as Sarcoptes scabiei, Demodex canis and Otodectes cynotis. This oral medication provides protection against flea, ticks, roundworms, hookworms and heartworms. A new product containing sarolaner, moxidectin and pyrantel (Simparica Trio-Zoetis) has recently been approved. These products are excellent for dogs that live in climates where fleas and ticks are more prevalent, and they are especially good for dogs that are bathed or go swimming frequently. Nearly 100% of fleas are killed within 8 hours, and more than 90% of ticks are killed within 48 hours. The onset of action for all isoxazoline products is between two and four hours. Isoxazolines work by selective inhibition of gamma-aminobutyric acid (GABA) and glutamate-gated chloride channels, resulting in hyper-excitation and death of fleas and ticks. They are absorbed systemically, so the fleas and ticks are killed only when they bite the animal. These products are extremely effective in treating and preventing fleas and ticks. The isoxazoline group of products is one of the newest on the market (see Table). Isoxazolines-the newest parasite control products And that’s fine, because many of the products available today are safe and effective, enabling veterinarians to recommend what’s best based on the individual animal’s lifestyle, environment and existing health conditions. If you ask 10 veterinarians which product(s) they recommend, you will likely get 10 different answers.
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Ideally, all pets should be protected year-round because fleas can live indoors even in the winter. The ideal flea control program involves eliminating the flea population on the pet, on all “in-contact” animals and in the environment. Fleas can also cause iron deficiency and blood loss, and serve as intermediate hosts for tapeworms and vectors for several diseases. The actual problem, of course, is hypersensitivity to the flea saliva. Flea allergy dermatitis is the most common cause of itching in dogs and cats.